Protein Modification Reagents
Enzo Life Sciences DTT (10g). CAS: 3483-12-3
Cell permeable protective agent for SH groups, maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively. ER-stress inducer. Alternative name: 1,4-Dithio-DL-threitol, DL-Dithiothreitol, Cleland's Reagent. Purity: ≥98% (Assay by Iodometric Titration). Appearance: White to off-white solid. Solubility: Soluble in water, 100% ethanol, acetone or ethyl acetate. Long Term Storage: +4°C.
Epigentek Inc DTT Solution (1 ml, 500 mM)
DTT, also known as Cleland's Reagent, is a particularly strong reducing agent, owing to its high conformational proprensity to form a six member ring with an internal disulfide bond. It has a redox potential of -0.33 V @ pH 7. It is used for many protein research applications, including reducing polyacrylamide electrophoresis (SDS-PAGE). The 500 mM stock solution can be directly used to achieve the amount of reducing agent required for your specific application.
Medchemexpress LLC Nε-(carboxyethyl)lysine-d4 | MFCD30364298 | 98.0% | 222.27 g/mol | C9H14D4N2O4 | 1 MG
Nε-(Carboxyethyl)lysine-d4 is a deuterium-labeled (d4) isotopic analogue of Nε-(carboxyethyl)lysine used as an internal standard for quantitative mass spectrometry and tracer studies. Supplied in small milligram quantities for analytical calibration, it supports accurate measurement of advanced glycation endproducts; consult the certificate of analysis for lot-specific purity, storage, and handling.
- Deuterium-labeled (d4) isotopic internal standard for mass spectrometry.
- Supplied in small, ready-to-use quantities suitable for trace analysis.
- Facilitates accurate quantitation of advanced glycation endproducts (AGEs).
- Compatible with common sample preparation and LC-MS workflows.
- Chemical formula C9H14D4N2O4 and molecular weight ~222.27 g/mol.
- Refer to the certificate of analysis for purity and storage details.
Sino Biological Assay Buffer and Co-factors: DTT Solution
1 M DTT solution used for preparing protein kinase assay buffer.
Supply Solutions DTT, 3483-12-3, MFCD00004877, 10g
Linear Formula HSCH2CH(OH)CH(OH)CH2SH, Molecular Weight 154.25, Synonym: 1,4-dithiothreitol, threo-1,4-Dimercapto-2,3-butanediol, DL-Dithiothreitol, Clelands reagent, DTT, cleland?s reagent, dithiothreitol; 1,4-dithiothreitol is commonly known as Cleland?s reagent. It confers protection to thiol groups and reduces disulfide bonds in peptides and proteins.[
AG Scientific Inc Dithiothreitol, DTT, 1 KG
Dithiothreitol (DTT), is a small-molecule redox reagent, known as Cleland's reagent, that forms a six-member ring with an internal disulfide bond. It has a redox potential of -0.33 V at pH 7. The reduction of typical disulfide bond proceeds by two sequential thiol-disulfide exchange reactions.DTT is effective in buffers to reduce protein disulfide bonds prior to SDS-PAGE. It can protect protein sulfhydryls and restore enzyme activity lost by oxidation.CAS Number: 3483-12-3Molecular Weight: 154.2Chemical Formula: C4H10O2S2Solubility: 10% solution in water. Clear and colorlessStorage Temperature: 2-8CResearch or further manufacturing use only, not for food or drug use.
Gold Biotechnology Inc DTT (Dithiothreitol) (> 99% pure) Protease free 25 g
Dithiothreitol (DTT) is the common name of the more popular of the two Cleland’s Reagents (the other being Dithioerythritol or DTE). DTT is a powerful reducing agent that forms a stable six-membered ring with an internal disulfide bond which is resistant to oxidation. DTT is often used for the following: reducing the disulfide bridge of the cross-linker N,N′-bis(acryloyl) cystamine to break apart the matrix of a polyacrylamide gel, the reduction of disulfide bonds in proteins, the prevention of those bonds from forming between cysteine residues and lastly, DTT is often used to reduce thiolated DNA in order to minimize dimerization.
Abcam Kinase Assay Buffer I, 1ML
Stock solution of buffer used for assaying kinase protein.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical DL-DIthIothreItol 25g
A reducing agent; has been used to stabilize thiols in a reduced state in various applications, including protein purification and enzymatic assays
Sigma Aldrich Fine Chemicals Biosciences DL-Dithiothreitol suitable for electrophoresis, >=99% | 3483-12-3 | MFCD00004877 | 5G
DL-Dithiothreitol suitable for electrophoresis, >=99% | Purity: >=99% | Mol Wt: 154.25 | 3483-12-3 | MFCD00004877 | 5G
Sigma Aldrich Fine Chemicals Biosciences DL-Dithiothreitol 98 (HPLC), 99.0 (titration), 3483-12-3, MFCD00004877
DL-Dithiothreitol 98 (HPLC), 99.0 (titration)
Enterprise Technology Solutions Seagate 8TB BarraCuda SATA III 3.5" 5400 rpm Internal HDD (OEM Packaging)
Designed for desktops, all-in-one PCs, home servers, and entry-level direct-attached storage (DAS) devices, the 8TB BarraCuda SATA III 3.5" Internal HDD from Seagate offers a storage capacity of up to 8TB and operates using a SATA III 6 Gb/s interface and a 256MB cache, both of which help to ensure uninterrupted data transfers
Medchemexpress LLC BTK degrader-1 | 2377645-56-0 | 99.4% | 925.03 | 5 MG
BTK degrader-1 is a Bruton's tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. It has an anti-tumor effect.
- For research use only
- To be handled by experienced personnel in appropriately equipped and authorized facilities
- Not fully validated for medical applications
Medchemexpress LLC PROTAC EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | 1 MG
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR. It induces degradation of EGFRdel19 and EGFRL858R/T790M with DC50s of 0.51 and 126 nM, respectively. The compound significantly inhibits the growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. The induced EGFR degradation is associated with autophagy.
- Displays excellent activity of inducing EGFRdel19 degradation with a DC50 value of 0.51 nM.
- Dramatically reduces the phosphorylation of EGFR and its downstream effector Akt in HCC827 and H1975 cell lines.
- Induces HCC827 cell line to undergo apoptosis at concentrations of 10 and 100 nM.
- Arrests both HCC827 and H1975 cell lines at G1 phase.